Effect of Resistance Exercise and Vitamin C Intake on Expression of Telomerase Reverse Transcriptase and Telomere Repeat Binding Factor-2 Genes and the Diameter and Number of Myofibrils in Old Rats

Objective: Cell aging is one of the most important and fundamental step in cellular behavior reduces muscle mass myofibrils. This study aims to investigate effect resistance exercise along with vitamin C consumption on expression Telomerase Reverse Transcriptase (TERT) Telomere Repeat Binding Factor-2 (TRF2) genes diameter number skeletal myofibrils old male Wistar rats. Methods: an experimental using control groups. Twenty-five rats (280-320 g aged 24 weeks) were randomly divided into five groups young control, old+resistance exercise, old+vitamin intake, exercise+vitamin control. In supplementation groups, received liposomal daily by gavage per body weight. Weight attached tail gradually increased during 8 weeks (weeks 1 2 50%; 3 4 5 6 75%; 7 100% total weight). Exercises performed at 3-5 sets 8-12 repetitions, or days a week. The Quantitative polymerase chain reaction method was used evaluate TERT TRF2 tissue. One-way ANOVA examine difference between Tukey’s post hoc test determine which significant. Results: Aging significantly reduced TERT, (P=0.001). Resistance intake had no significant (P≥0.05), but caused increase (P= 0.001). Conclusion: Eight can